Set in downtown New York in 1900, 'The Knick' is centered on the Knickerbocker Hospital and its staff, notably Dr. John Thackery, the hospital's brilliant chief surgeon who pushes medicine's boundaries, pioneering new procedures despite a severe drug addiction.
| Actor | Role |
|---|---|
 Clive OwenDr. John Thackery | Dr. John Thackery |
 Charles AitkenHenry Robertson | Henry Robertson |
 André HollandDr. Algernon Edwards | Dr. Algernon Edwards |
 Jeremy BobbHerman Barrow | Herman Barrow |
 Juliet RylanceCornelia Robertson | Cornelia Robertson |
 Eve HewsonLucy Elkins | Lucy Elkins |
 Eric JohnsonDr. Everett Gallinger | Dr. Everett Gallinger |
 Michael AngaranoDr. Bertram “Bertie" Chickering, Jr. | Dr. Bertram “Bertie" Chickering, Jr. |
 Cara SeymourSister Harriet | Sister Harriet |
 Chris SullivanTom Cleary | Tom Cleary |