Focuses on a group of toddlers, most prominently Tommy, Chuckie, Phil, Lil, and Angelica, and their day-to-day lives, usually involving common life experiences that become adventures in the babies' imaginations. Adults in the series are almost always unaware of what the children are up to; however, this only provides more room for the babies to explore and discover their surroundings.
| Actor | Role |
|---|---|
 E. G. DailyTommy Pickles (voice) | Tommy Pickles (voice) |
 Kath SouciePhil DeVille / Lil DeVille (voice) | Phil DeVille / Lil DeVille (voice) |
 Cheryl ChaseAngelica Pickles (voice) | Angelica Pickles (voice) |
 Dionne QuanKimi Finster (voice) | Kimi Finster (voice) |
 Tara StrongDil Pickles (voice) | Dil Pickles (voice) |
 Joe AlaskeyLou Pickles (voice) | Lou Pickles (voice) |
 Melanie ChartoffDidi Pickles (voice) | Didi Pickles (voice) |
 Tress MacNeilleCharlotte Pickles (voice) | Charlotte Pickles (voice) |
 Jack RileyStu Pickles (voice) | Stu Pickles (voice) |
 Cree SummerSusie Carmichael (voice) | Susie Carmichael (voice) |
 Nancy CartwrightChuckie Finster (voice) | Chuckie Finster (voice) |
 Michael BellDrew Pickles / Chas Finster (voice) | Drew Pickles / Chas Finster (voice) |