A man is tasked with driving his embittered 80-year-old father-in-law cross country to be legally euthanized in Oregon, while along the way helping him rediscover a reason for living.
| Actor | Role |
|---|---|
 Frank LangellaRaymond | Raymond |
 Billy CrudupBrian | Brian |
 Christina ApplegateKate | Kate |
 Mary Kay PlaceEstelle | Estelle |
 Josh LucasDanny | Danny |
 Nicola PeltzAnnie | Annie |
 Alex ShafferNick | Nick |
 Maryann PlunkettMaryanne | Maryanne |
 Robert HoganPeter | Peter |
 Keenan JolliffColt | Colt |
 James MurtaughDr. Feldstein | Dr. Feldstein |
 Michael GodereTom | Tom |
 Geoffrey OwensDr. Roma | Dr. Roma |
 Aaron YooMotel Clerk | Motel Clerk |
 Ann HaradaCompassionate Aide | Compassionate Aide |
 Jimmy PalumboMarv | Marv |
 Will JanowitzRalph | Ralph |
 Rebecca BlumhagenAva | Ava |
 Alberto BonillaAccented Waiter | Accented Waiter |
 Odiseas GeorgiadisMale Student | Male Student |
| JJavier SpiveyEffette Student | Effette Student |
 Nilaja SunSecretary | Secretary |
| MMatthew A. JacobsConcerned Trucker | Concerned Trucker |
 Edward HibbertAudubon Expert (voice) | Audubon Expert (voice) |
 Carla QuevedoGilda (uncredited) | Gilda (uncredited) |