In World War II Washington DC, scientist Pat Jamieson's assistant, Jamie Rowan, enters a loveless marriage with him. Struggles bring them closer together.
| Actor | Role |
|---|---|
 Spencer TracyPat Jamieson | Pat Jamieson |
 Katharine HepburnJamie Rowan | Jamie Rowan |
 Lucille BallKitty Trimble | Kitty Trimble |
 Keenan WynnQuentin Ladd | Quentin Ladd |
 Carl EsmondPaul Carrell | Paul Carrell |
 Patricia MorisonEdwina Collins | Edwina Collins |
 Felix BressartProfessor Grinza | Professor Grinza |
| EEmily MasseyAnna | Anna |
 Gloria GrahameFlower Girl | Flower Girl |
 George DavisCaretaker | Caretaker |
 George ChandlerElevator Boy | Elevator Boy |
 Clancy CooperSergeant | Sergeant |
 Clarence MuseTrain Porter (uncredited) | Train Porter (uncredited) |
 Eddie AcuffTaxi Driver (uncredited) | Taxi Driver (uncredited) |