The fireworks begin when Madea’s family gathers for her granddaughter’s wedding. As usual, Madea rules the roost, as she and her neighbor, the wacky Mr. Brown, deliver nonstop laughs. Live, love, rejoice...it’s Madea’s Family Reunion!
| Actor | Role |
|---|---|
 Tyler PerryMable 'Madea' Simmons | Mable 'Madea' Simmons |
| DD'atra HicksJackie Simmons | Jackie Simmons |
| TTerrell PhillipsKevin | Kevin |
 Tamela MannCora Jean Simmons | Cora Jean Simmons |
 David MannLeroy Brown | Leroy Brown |
| QQuan HowellReverend Johnny Lewis | Reverend Johnny Lewis |
| PPebbles JohnsonVickie | Vickie |
| GGary JenkinsA.J. Jenkins | A.J. Jenkins |
| ZZakiya WilliamsTina Simmons | Tina Simmons |
| SSonya EvansLisa Simmons-Jenkins | Lisa Simmons-Jenkins |
| MMike StormRonnie | Ronnie |
| RRegina McCraryMattie Brown | Mattie Brown |
| JJames Tittle IVBrian | Brian |
| KKim EasterlingAquaessha Brown | Aquaessha Brown |