After a deadly storm, Tom and Jerry find themselves stranded on an unknown island ruled by the evil Wizard of Oz. As they try to find their way back home, they worry for their master Dorothy's safety.
| Actor | Role |
|---|---|
 Grey DeLisleDorothy (voice) | Dorothy (voice) |
 Joe AlaskeyWizard of Oz / Butch / Droopy (voice) | Wizard of Oz / Butch / Droopy (voice) |
 Michael GoughScarecrow (voice) | Scarecrow (voice) |
 Rob PaulsenTin Man (voice) | Tin Man (voice) |
 Todd StashwickCowardly Lion (voice) | Cowardly Lion (voice) |
 Frances ConroyAuntie Em / Glinda (voice) | Auntie Em / Glinda (voice) |
 Laraine NewmanWicked Witch of the West (voice) | Wicked Witch of the West (voice) |
 Stephen RootUncle Henry / Crows (voice) | Uncle Henry / Crows (voice) |
 Kath SoucieTuffy the Munchkin Mouse (voice) | Tuffy the Munchkin Mouse (voice) |
 Nikki YanofskyDorothy (singing voice) | Dorothy (singing voice) |
 Billy WestTom (voice) (uncredited) | Tom (voice) (uncredited) |