When precocious twins Sarah and Julie feel like Mom is tired of them, they take off on an exciting adventure to their grandmother's house and encounter a pair of villains along the way.
| Actor | Role |
|---|---|
 Ashley OlsenJulie Thompson | Julie Thompson |
 Mary-Kate OlsenSarah Thompson | Sarah Thompson |
 Rhea PerlmanShirley | Shirley |
 Cynthia GearyRhonda Thompson | Rhonda Thompson |
 J. Eddie PeckEddie Popko | Eddie Popko |
 Stuart MargolinDet. Gremp | Det. Gremp |
 Jerry Van DykeHarvey | Harvey |
| RRick PoltarukSanta | Santa |
 Leslie CarlsonDoorman | Doorman |
| FFlorence PatersonGrandmother | Grandmother |
| AAndrew WheelerPoliceman | Policeman |
 Venus TerzoStacey | Stacey |
| WWalter MarshCrotchety Man | Crotchety Man |
| FFrank LewisSaxophone Player | Saxophone Player |
| DDoreen RamusOld Woman on Bus | Old Woman on Bus |
| BByron LucasCustomer | Customer |
 John DestrySecurity Guard | Security Guard |
| DDebbie GregoryAnchor Woman | Anchor Woman |
 Lorena GaleWaitress | Waitress |
 Bob SagetWin-O-Lotto Lottery Host (uncredited) | Win-O-Lotto Lottery Host (uncredited) |
 Lori LoughlinWin-O-Lotto Hostess (uncredited) | Win-O-Lotto Hostess (uncredited) |
 Candace Cameron BureTeen in Audience (uncredited) | Teen in Audience (uncredited) |
| MMichael MichelucciPool Player (uncredited) | Pool Player (uncredited) |