While AIDS may be one of the most feared diseases of modern times, there is still a degree of scientific debate over the subject of just how the disease originated, and how the first cases spread. Two filmmakers explore a controversial theory about the beginnings of the disease. Using interviews, newsreel footage, and documented research experiments, The Origin of AIDS examines how a combination of benevolence, careless lab procedures, and the need of a desperate few to cover their tracks could have led to one of the most serious pandemics of the 20th century.