Set against the backdrop of the infamous Theatre Grand Guignol the story revolves around iconic actress Paula Maxa - the most famous of the Grand Guignol's leading ladies and the titular Most Assassinated Woman, who was graphically slain on stage multiple times a day.
| Actor | Role |
|---|---|
 Anna MouglalisPaula Maxa | Paula Maxa |
 Niels SchneiderJean | Jean |
 Éric GodonGeorges | Georges |
 André WilmsEugène | Eugène |
| MMichel FauAndré | André |
 Constance DolléViolette | Violette |
 Jean-Michel BalthazarPaul | Paul |
 Jean-Jacques RausinAlexandre | Alexandre |
 Sissi DuparcRose | Rose |
 Vérane FrédianiSylviane | Sylviane |
 Renaud RuttenLouis | Louis |
 Julie RecoingJulie | Julie |
 Christian CrahayDupuis | Dupuis |
 Maya ColineAimée | Aimée |
 Pierre NisseLe Guichetier | Le Guichetier |
 Keren AnnNot listed | Not listed |
 Selma AlaouiNot listed | Not listed |
| PPhilippe LegrosRégisseur théâtre | Régisseur théâtre |
 André PasquasyHomme de main | Homme de main |