Detective Nayland Smith, comissioned by the British Government to investigate a series of murders comes up against the "Coughing Horror", Dr Fu-Manchu's servant.
| Actor | Role |
|---|---|
| HH. Agar LyonsDr. Fu Manchu | Dr. Fu Manchu |
 Fred PaulNayland Smith | Nayland Smith |
 Dorinea ShirleyKaramaneh | Karamaneh |
| HHumberston WrightDr. Petrie | Dr. Petrie |
| FFred MorganAntonio Strozza | Antonio Strozza |
| JJohnny ButtFarmer | Farmer |
| HHarry RignoldCoughing Horror | Coughing Horror |