Thankam follows the story of Muthu and Kannan, two gold agents from Thrissur, known as the gold capital of India. As they travel across Kerala and Tamil Nadu, delivering consignments of gold, their lives take a dark turn when a routine trip leads to unexpected complications.
| Actor | Role |
|---|---|
 Biju MenonMuthu | Muthu |
 Vineeth SreenivasanKannan | Kannan |
 Aparna BalamuraliKeerthy | Keerthy |
 Girish KulkarniJayanth Sakhalkar | Jayanth Sakhalkar |
 Kochu PremanSasipillai | Sasipillai |
 Vineeth Thattil DavidBejoy | Bejoy |
| IIndira PrasadAmbika Chechi | Ambika Chechi |
 KalaiyarasanAbbas | Abbas |
 Jain AndrewsAlex | Alex |
| VVigneshwar SureshVicky | Vicky |
| AAbdul JabbarArul | Arul |
| NNitin DhandukeBhaskar Dhanduke | Bhaskar Dhanduke |
 Srikant MuraliMani Kurup | Mani Kurup |
| SSowmiya MurugesanThamara | Thamara |
 Anupama SomanadhanSheena | Sheena |
| YYashpal SarnatYashpal | Yashpal |