Armed with only one word - Tenet - and fighting for the survival of the entire world, the Protagonist journeys through a twilight world of international espionage on a mission that will unfold in something beyond real time.
| Actor | Role |
|---|---|
 John David WashingtonProtagonist | Protagonist |
 Robert PattinsonNeil | Neil |
 Elizabeth DebickiKat | Kat |
 Kenneth BranaghSator | Sator |
 Dimple KapadiaPriya | Priya |
 Michael CaineCrosby | Crosby |
 Martin DonovanFay | Fay |
 Fiona DourifWheeler | Wheeler |
 Yuri KolokolnikovVolkov | Volkov |
 Himesh PatelMahir | Mahir |
 Clémence PoésyBarbara | Barbara |
 Aaron Taylor-JohnsonIves | Ives |
 Laurie ShepherdMax | Max |
 Anthony MolinariRohan | Rohan |
 Juhan UlfsakPassenger | Passenger |
 Jefferson HallWell-dressed Man | Well-dressed Man |
 Ivo UukkiviUniformed Official | Uniformed Official |
 Andrew HowardDriver | Driver |
 Rich Ceraulo KoSWAT / Target | SWAT / Target |
 Jonathan CampSWAT 2 | SWAT 2 |
 Wes ChathamSWAT 3 | SWAT 3 |
 Sander RebaneUkrainian SWAT | Ukrainian SWAT |
 Josh StewartMale Voice (voice) | Male Voice (voice) |
 Denzil SmithSanjay | Sanjay |
 Jeremy TheobaldSteward | Steward |
| TTom NolanShipley's Representive | Shipley's Representive |
 Marcel SabatGaunt Russian | Gaunt Russian |
 Julia-Maria ArnoldsNanny | Nanny |
 Jack Cutmore-ScottKlaus | Klaus |
 Adam CropperYoung Sator | Young Sator |