 Tobey MaguireSpider-Man / Peter Parker | Spider-Man / Peter Parker |
 Willem DafoeGreen Goblin / Norman Osborn | Green Goblin / Norman Osborn |
 Kirsten DunstMary Jane Watson | Mary Jane Watson |
 James FrancoHarry Osborn | Harry Osborn |
 Cliff RobertsonBen Parker | Ben Parker |
 Rosemary HarrisMay Parker | May Parker |
 J.K. SimmonsJ. Jonah Jameson | J. Jonah Jameson |
 Joe ManganielloFlash Thompson | Flash Thompson |
 Gerry BeckerMaximilian Fargas | Maximilian Fargas |
 Bill NunnJoseph 'Robbie' Robertson | Joseph 'Robbie' Robertson |
 Jack BettsHenry Balkan | Henry Balkan |
 Stanley AndersonGeneral Slocum | General Slocum |
 Ron PerkinsDr. Mendel Stromm | Dr. Mendel Stromm |
 Michael PapajohnCarjacker | Carjacker |
 K.K. DoddsSimkins | Simkins |
 Ted RaimiHoffman | Hoffman |
 Bruce CampbellRing Announcer | Ring Announcer |
 Elizabeth BanksMiss Brant | Miss Brant |
 John PaxtonHouseman | Houseman |
 Tim DeZarnPhilip Watson | Philip Watson |
 Taylor GilbertMadeline Watson | Madeline Watson |
 Randy PoffoBone Saw McGraw | Bone Saw McGraw |
 Larry JoshuaWrestling Promoter | Wrestling Promoter |
 Timothy Patrick QuillWrestling Arena Guard | Wrestling Arena Guard |
 Lisa DanielleBone-ette | Bone-ette |
 Natalie T. YeoBone-ette | Bone-ette |
 Erica D. PorterBone-ette | Bone-ette |
 Kristen DavidsonBone-ette | Bone-ette |
 Jason PadgettFlash's Crony | Flash's Crony |
 Shan Omar HueyTeacher | Teacher |
