Pope Francis responds to questions from around the world, discussing topics including ecology, immigration, consumerism and social justice.
| Actor | Role |
|---|---|
 Pope FrancisSelf | Self |
 Ignazio OlivaFrancesco d'Assisi | Francesco d'Assisi |
| SSister María Eufemia GoycoecheaSelf | Self |
 Joe BidenSelf - Former Vice President | Self - Former Vice President |
 Daniele De AngelisFriar | Friar |
 Carlo FalconettiFriar | Friar |
 Evo MoralesSelf | Self |
 Paul RyanSelf | Self |
 Angela MerkelSelf (uncredited) | Self (uncredited) |
 Melania TrumpSelf - First Lady (uncredited) | Self - First Lady (uncredited) |
 John KerrySelf (uncredited) | Self (uncredited) |
 Barack ObamaSelf - Former President (uncredited) | Self - Former President (uncredited) |
 Samantha PowerSelf (uncredited) | Self (uncredited) |
 Vladimir PutinSelf (uncredited) | Self (uncredited) |
 Recep Tayyip ErdoğanSelf (uncredited) | Self (uncredited) |
 Donald TrumpSelf - President (uncredited) | Self - President (uncredited) |
 Wim WendersSelf - Narrator (voice) (uncredited) | Self - Narrator (voice) (uncredited) |