New York, I Love You delves into the intimate lives of New Yorkers as they grapple with, delight in and search for love. Journey from the Diamond District in the heart of Manhattan, through Chinatown and the Upper East Side, towards the Village, into Tribeca, and Brooklyn as lovers of all ages try to find romance in the Big Apple.
| Actor | Role |
|---|---|
 Natalie PortmanRifka | Rifka |
 Hayden ChristensenBen | Ben |
 Bradley CooperGus | Gus |
 Ethan HawkeWriter | Writer |
 Shia LaBeoufJacob | Jacob |
 Andy GarciaGarry | Garry |
 Orlando BloomDavid | David |
 Chris CooperAlex | Alex |
 Anton YelchinBoy in the Park | Boy in the Park |
 Robin WrightAnna | Anna |
 Olivia ThirlbyActress | Actress |
 Maggie QCall Girl | Call Girl |
 Christina RicciCamille | Camille |
 Irrfan KhanMansukhbhai | Mansukhbhai |
 Julie ChristieIsabelle | Isabelle |
 Drea de MatteoLydia | Lydia |
 Rachel BilsonMolly | Molly |
 James CaanMr. Riccoli, the Pharmacist | Mr. Riccoli, the Pharmacist |
 Blake LivelyEx-Girlfriend | Ex-Girlfriend |
 John HurtBellhop | Bellhop |
 Taylor GeareTeya | Teya |
 Carlos AcostaDante | Dante |
 Jacinda BarrettMaggie | Maggie |
 Uğur YücelPainter | Painter |
 Shu QiChinese Herbalist | Chinese Herbalist |
 Burt YoungLandlord | Landlord |
 Eli WallachAbe | Abe |
 Cloris LeachmanMitzie | Mitzie |
 Emilie OhanaZoe, the Video Artist | Zoe, the Video Artist |
 Eva AmurriSarah | Sarah |