The Medicine Seller returns as the Edo harem faces a new crisis, with family feuds, inner turmoil and fiery envy igniting the birth of a raging spirit.
| Actor | Role |
|---|---|
 Hiroshi KamiyaMedicine Seller (voice) | Medicine Seller (voice) |
 ChoYoshimichi Tokita (voice) | Yoshimichi Tokita (voice) |
 Daisuke HosomiSakashita (voice) | Sakashita (voice) |
 Haruka TomatsuBotan Otomo (voice) | Botan Otomo (voice) |
 Kenyu HoriuchiRoju Otomo (voice) | Roju Otomo (voice) |
 Tomoyo KurosawaAsa (voice) | Asa (voice) |
 Yoko HikasaFuki Tokita (voice) | Fuki Tokita (voice) |
 Yuki KajiSaburomaru Tokita (voice) | Saburomaru Tokita (voice) |
 Ryo HorikawaFujimaki (voice) | Fujimaki (voice) |
 Naomi KusumiKatsunuma (voice) | Katsunuma (voice) |
 Yoshiko SakakibaraSuikoin (voice) | Suikoin (voice) |
 YukanaSayo (voice) | Sayo (voice) |
 Atsumi TanezakiSachiko (voice) | Sachiko (voice) |