The live special event features reenactments of episodes from “The Facts of Life” and “Diff’rent Strokes”.
| Actor | Role |
|---|---|
 Jennifer AnistonBlair Warner | Blair Warner |
 Ann DowdEdna Garrett | Edna Garrett |
 Kathryn HahnJo Polniaczek | Jo Polniaczek |
 Gabrielle UnionDorothy 'Tootie' Ramsey | Dorothy 'Tootie' Ramsey |
 Allison TolmanNatalie Green | Natalie Green |
 John LithgowPhilip Drummond | Philip Drummond |
 Kevin HartArnold Drummond | Arnold Drummond |
 Damon WayansWillis Drummond | Willis Drummond |
 Jon StewartCarl 'Rocky' Price | Carl 'Rocky' Price |
 Will ArnettDink Lockwood | Dink Lockwood |
 Jason BatemanTim Holifield | Tim Holifield |
 Snoop DoggVernon | Vernon |
 Norman LearSelf - Host | Self - Host |
 Jimmy KimmelSelf - Host | Self - Host |
 Lisa WhelchelSelf | Self |
 Mindy CohnSelf | Self |
 Kim FieldsSelf | Self |
 Todd BridgesSelf | Self |
 Wanyá MorrisSelf | Self |
 Shawn StockmanSelf | Self |