 Leonardo DiCaprioErnest Burkhart | Ernest Burkhart |
 Robert De NiroWilliam Hale | William Hale |
 Lily GladstoneMollie Burkhart | Mollie Burkhart |
 Jesse PlemonsTom White | Tom White |
 Tantoo CardinalLizzie Q | Lizzie Q |
 John LithgowProsecutor Peter Leaward | Prosecutor Peter Leaward |
 Brendan FraserW.S. Hamilton | W.S. Hamilton |
 Cara Jade MyersAnna | Anna |
 JaNae CollinsReta | Reta |
 Jillian DionMinnie | Minnie |
 Jason IsbellBill Smith | Bill Smith |
 William BelleauHenry Roan | Henry Roan |
 Louis CancelmiKelsie Morrison | Kelsie Morrison |
 Scott ShepherdByron Burkhart | Byron Burkhart |
| EEverett WallerPaul Red Eagle | Paul Red Eagle |
| TTahlee RedcornNon-Hon-Zhin-Ga / Traditional Leader | Non-Hon-Zhin-Ga / Traditional Leader |
 Yancey Red CornChief Bonnicastle | Chief Bonnicastle |
 Tatanka MeansJohn Wren | John Wren |
 Tommy SchultzBlackie Thompson | Blackie Thompson |
 Sturgill SimpsonHenry Grammer | Henry Grammer |
 Ty MitchellJohn Ramsey | John Ramsey |
 Gary BasarabaDetective Burns | Detective Burns |
 Charlie MusselwhiteAlvin Reynolds | Alvin Reynolds |
 Pat HealyAgent John Burger | Agent John Burger |
 Steve WittingDr. James Shoun | Dr. James Shoun |
 Steve RoutmanDr. David Shoun | Dr. David Shoun |
 Gene JonesPitts Beatty | Pitts Beatty |
 Michael Abbott Jr.Agent Frank Smith | Agent Frank Smith |
 J.C. MacKenzieRadio Announcer | Radio Announcer |
 Jack WhiteRadio Show Actor | Radio Show Actor |
