With their most formidable foe vanquished, Inuyasha and his comrades begin returning to their everyday lives. But their peace is fleeting as another adversary emerges: Kaguya, the self-proclaimed princess from the Moon of Legend, hatches a plot to plunge the world into an eternal night of the full moon. Inuyasha, Kagome, Miroku, Sango and Shippou must reunite to confront the new menace.
| Actor | Role |
|---|---|
 Kappei YamaguchiInuyasha (voice) | Inuyasha (voice) |
 Satsuki YukinoKagome Higurashi (voice) | Kagome Higurashi (voice) |
 Koji TsujitaniMiroku (voice) | Miroku (voice) |
 Houko KuwashimaSango (voice) | Sango (voice) |
 Kumiko WatanabeShippo (voice) | Shippo (voice) |
 Noriko HidakaKikyo (voice) | Kikyo (voice) |
 Kenichi OgataMyōga (voice) | Myōga (voice) |
 Toshiyuki MorikawaNaraku (voice) | Naraku (voice) |
 Izumi ŌgamiKagura (voice) | Kagura (voice) |
 YukanaKanna (voice) | Kanna (voice) |
 Akiko YajimaKohaku (voice) | Kohaku (voice) |
 Mieko HaradaKaguya (voice) | Kaguya (voice) |