A look into the lives of Malawi's 1 million plus orphans in the wake of the AIDS pandemic. It offers hope and real solutions to the challenges that people face living in extreme poverty.
| Actor | Role |
|---|---|
 MadonnaSelf / Narrator (voice) | Self / Narrator (voice) |
 Paul FarmerSelf | Self |
 Desmond TutuSelf | Self |
 Jeffrey SachsSelf | Self |
 Bill ClintonSelf | Self |
 David BandaSelf | Self |
 Lourdes LeonSelf | Self |
| AAleke BandaSelf | Self |
| MMathews ChikaondaSelf | Self |
| EEric BorgsteinSelf | Self |
| VVictoria KeelanSelf | Self |
| CCallista Chapola ChimomboSelf | Self |
| JJoyce BandaSelf | Self |
| HHeath GrantSelf | Self |
| JJoshua ChirwaSelf | Self |
 Hastings BandaSelf (archive footage) (uncredited) | Self (archive footage) (uncredited) |