 Kiefer O'ReillyHoward Lovecraft (Voice) | Howard Lovecraft (Voice) |
 Jeffrey CombsH.P. Lovecraft (voice) | H.P. Lovecraft (voice) |
 Tyler NicolWinfield Lovecraft (voice) | Winfield Lovecraft (voice) |
| MMichelle MyersSarah Lovecraft (voice) | Sarah Lovecraft (voice) |
| SSean Patrick O'ReillySpot / Cthulhu (voice) | Spot / Cthulhu (voice) |
 Alison WandzuraMary Lovecraft (voice) | Mary Lovecraft (voice) |
 Mark HamillDr. Henry Armitage (voice) | Dr. Henry Armitage (voice) |
| VVijary Vaibhav SainiProfessor Jaswant Atwood (voice) | Professor Jaswant Atwood (voice) |
 Ashleigh BallEllen Ellery (voice) | Ellen Ellery (voice) |
 Scott McNeilHamish Rice / Govlins (voice) | Hamish Rice / Govlins (voice) |
 Nick WolfhardWilliam Dyer (voice) | William Dyer (voice) |
 Christopher PlummerDr. Jeffrey West (voice) | Dr. Jeffrey West (voice) |
 Finn WolfhardHerbert West (voice) | Herbert West (voice) |
 Doug BradleyNyarlathotep (voice) | Nyarlathotep (voice) |
| SSummer O'ReillyGotha (voice) | Gotha (voice) |
| HHarmony O'ReillyInnes (voice) | Innes (voice) |
| PPhoenix O'ReillyTwi'i (voice) | Twi'i (voice) |
