Victor Frankenstein witnesses his creation turn uncontrollable after he's duped by his associate, Dr. Polidori.
| Actor | Role |
|---|---|
 James MasonDr. John Polidori | Dr. John Polidori |
 Leonard WhitingVictor Frankenstein | Victor Frankenstein |
 David McCallumDr. Clervall | Dr. Clervall |
 Jane SeymourAgatha / Prima | Agatha / Prima |
 Nicola PagettElizabeth Fanschawe | Elizabeth Fanschawe |
 Michael SarrazinThe Creature | The Creature |
 Michael WildingSir Richard Fanshawe | Sir Richard Fanshawe |
 Tom BakerSea Captain | Sea Captain |
 Clarissa Kaye-MasonLady Fanschawe | Lady Fanschawe |
 Agnes MooreheadMrs. Blair | Mrs. Blair |
 Margaret LeightonFrancoise DuVal | Francoise DuVal |
 Ralph RichardsonMr. Lacey | Mr. Lacey |
 John GielgudChief Constable | Chief Constable |
 Peter SallisPriest | Priest |
 Yootha JoyceHospital Matron | Hospital Matron |
 Dallas AdamsFelix | Felix |
 Julian BarnesYoung Man | Young Man |
 Karl HowmanWilliam Frankenstein | William Frankenstein |