Jan Randall, whose brain is affected by inoperable cancer, is deeply afraid of being trapped inside. Refusing to take medications that would reduce her final days to a hospital bed, she moves into a tent in her backyard. Determined to give her one last gift, her husband John courageously takes her on a trip around the world—on foot, in their own hometown—for what is truly the trip of a lifetime.
| Actor | Role |
|---|---|
 Susan SarandonJan Randall | Jan Randall |
 William H. MacyJohn Randall | John Randall |
 Marcia CrossMonica Freeman | Monica Freeman |
 Kim CoatesNot listed | Not listed |
 Roberta ColindrezNot listed | Not listed |
 Amy SedarisNot listed | Not listed |
 Ethan SlaterNot listed | Not listed |
 Christopher JacksonNot listed | Not listed |