Pauline, a disturbed, outcast teenager, has a fascination with surgery and experiences violent, psychosexual fantasies, all while aspiring to a career in medicine.
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Pauline, a disturbed, outcast teenager, has a fascination with surgery and experiences violent, psychosexual fantasies, all while aspiring to a career in medicine.
| Actor | Role |
|---|---|
 AnnaLynne McCordPauline | Pauline |
 Traci LordsPhyllis | Phyllis |
 Ariel WinterGrace | Grace |
 Roger BartBob | Bob |
 Jeremy SumpterAdam | Adam |
 John WatersWilliam | William |
 Malcolm McDowellMr. Cooper | Mr. Cooper |
 Marlee MatlinAmber | Amber |
 Matthew Gray GublerMr. Claybaugh | Mr. Claybaugh |
 Ray WisePrincipal Campbell | Principal Campbell |
 Molly McCookNatalie | Natalie |
 Natalie DreyfussAbigail | Abigail |
 Cole BernsteinKimberly | Kimberly |
 Matthew FaheyNathan | Nathan |
 Sidney FranklinTimothy | Timothy |
 Brennan BaileySebastian | Sebastian |
| EEmily BicksBreanna | Breanna |
 Cameron AllenYoung Pauline | Young Pauline |
 Rachel Ann MullinsZombie (uncredited) | Zombie (uncredited) |