A kindly, elderly couple who run a New York City boarding house form the steady center around which the lives and loves of their various residents unfold. Borrowed money, a lovelorn chorus girl, and a tragic misunderstanding set in motion the chain of events in East of Fifth Avenue’s tender pageant of life.
| Actor | Role |
|---|---|
 Wallace FordVic Howard | Vic Howard |
 Dorothy TreeKitty Green | Kitty Green |
 Mary CarlisleEdna Howard | Edna Howard |
 Walter ConnollyJohn Lawton | John Lawton |
 Louise CarterMrs. Mary Lawton | Mrs. Mary Lawton |
 Walter ByronPaul Baxter | Paul Baxter |
 Lucien LittlefieldGardner | Gardner |
 Harry HolmanSam Cronin | Sam Cronin |
 Maude EburneMrs. Conway | Mrs. Conway |
 Willard RobertsonDr. Morgan | Dr. Morgan |
 Fern EmmettLizzie | Lizzie |
 Bradley PageNick | Nick |
| KKate CampbellMiss Smythe | Miss Smythe |