| PPhil BorgesNarrator (voice) | Narrator (voice) |
| AAdam GentrySelf – Seattle, Washington | Self – Seattle, Washington |
| RRob GentrySelf – Adam's Father | Self – Adam's Father |
| JJodi GentrySelf – Adam's Mother | Self – Adam's Mother |
| RRon ZuelzkeSelf – Adam's High School Friend | Self – Adam's High School Friend |
| EErica MillerSelf – Adam's High School Girlfriend | Self – Adam's High School Girlfriend |
| EEkhaya EsimaSelf | Self |
| RRobert WhitakerSelf – Journalist, Author, 'Anatomy of An Epidemic' | Self – Journalist, Author, 'Anatomy of An Epidemic' |
| AAllen J. FrancesSelf – Author; Prof. Emeritus, Dept. Psychiatry, Duke University | Self – Author; Prof. Emeritus, Dept. Psychiatry, Duke University |
| DDwayne StoneSelf – Mental Health Counselor, Psychiatric Community Clinic | Self – Mental Health Counselor, Psychiatric Community Clinic |
| TThupten NgodrupSelf | Self |
| SSandra IngermanSelf – Therapist, Author, Shamanic Practitioner | Self – Therapist, Author, Shamanic Practitioner |
| RRoger WalshSelf - Professor Psychiatry & Anthropology, UC Irvine | Self - Professor Psychiatry & Anthropology, UC Irvine |
 Gabor MatéSelf – Author; Professor, Simon Fraser Univ., BC, Canada | Self – Author; Professor, Simon Fraser Univ., BC, Canada |
| WWill HallSelf – Therapist & Teacher; Author, Lecturer | Self – Therapist & Teacher; Author, Lecturer |
| PPeter GøtzscheSelf – Medical Researcher; Professor, University of Copenhagen | Self – Medical Researcher; Professor, University of Copenhagen |
| DDaniel J. SiegelSelf – Neuropsychiatrist | Self – Neuropsychiatrist |
| MMia DavisSelf – Ekhaya's Friend | Self – Ekhaya's Friend |
| TTren ChildsSelf – Ekhaya's Friend | Self – Ekhaya's Friend |
| SSara PelfreySelf – Founder, SoulFood Coffee House | Self – Founder, SoulFood Coffee House |
| MMakia OaksSelf – Co-Owner, SoulFood Coffee House | Self – Co-Owner, SoulFood Coffee House |
| RRobert ThurmanSelf – Professor, Buddhist Studies, Colombia University; Author | Self – Professor, Buddhist Studies, Colombia University; Author |
| JJoan HalifaxSelf – Buddhist Teacher, Zen Priest, Author, Anthropologist | Self – Buddhist Teacher, Zen Priest, Author, Anthropologist |
| JJohn ReadSelf – Author; Professor, Swinburne Univ. of Technology, NZ | Self – Author; Professor, Swinburne Univ. of Technology, NZ |
| AAlberto VilloldoSelf – Psychologist, Author, Medical Anthropologist | Self – Psychologist, Author, Medical Anthropologist |
| JJames BarazSelf – Co-Founder, Spirit Rock Meditation Center | Self – Co-Founder, Spirit Rock Meditation Center |
| AAngeles ArrienSelf – Cultural Anthropologist, Educator, Author | Self – Cultural Anthropologist, Educator, Author |
| CCarroll DunhamSelf – Medical Anthropologist, Author, Filmmaker | Self – Medical Anthropologist, Author, Filmmaker |
| KKrista MacKinnonSelf – Founder & Director, Families Healing Together | Self – Founder & Director, Families Healing Together |
 Stanislav GrofSelf – Psychiatrist, Author; Professor of Psychology, CIIS | Self – Psychiatrist, Author; Professor of Psychology, CIIS |