 Anthony GonzalezMiguel Rivera (voice) | Miguel Rivera (voice) |
 Gael García BernalHéctor (voice) | Héctor (voice) |
 Benjamin BrattErnesto de la Cruz (voice) | Ernesto de la Cruz (voice) |
 Alanna UbachMamá Imelda (voice) | Mamá Imelda (voice) |
 Renée VictorAbuelita (voice) | Abuelita (voice) |
 Jaime CamilPapá (voice) | Papá (voice) |
 Alfonso ArauPapá Julio (voice) | Papá Julio (voice) |
 Herbert SiguenzaTío Oscar / Tío Felipe (voice) | Tío Oscar / Tío Felipe (voice) |
 Gabriel IglesiasClerk (voice) | Clerk (voice) |
 Lombardo BoyarPlaza Mariachi / Gustavo (voice) | Plaza Mariachi / Gustavo (voice) |
 Ana Ofelia MurguíaMamá Coco (voice) | Mamá Coco (voice) |
 Natalia Cordova-BuckleyFrida Kahlo (voice) | Frida Kahlo (voice) |
 Sofía EspinosaMamá (voice) | Mamá (voice) |
 Selene LunaTía Rosita (voice) | Tía Rosita (voice) |
 Edward James OlmosChicharrón (voice) | Chicharrón (voice) |
| CCarla MedinaDepartures Agent / Additional Voices (voice) | Departures Agent / Additional Voices (voice) |
 Dyana OrtelliTía Victoria / Additional Voices (voice) | Tía Victoria / Additional Voices (voice) |
 Luis ValdezTío Berto / Don Hidalgo (voice) | Tío Berto / Don Hidalgo (voice) |
 Blanca AraceliEmcee (voice) | Emcee (voice) |
 Salvador ReyesSecurity Guard (voice) | Security Guard (voice) |
 Cheech MarinCorrections Officer (voice) | Corrections Officer (voice) |
| OOctavio SolisArrivals Agent (voice) | Arrivals Agent (voice) |
 John RatzenbergerJuan Ortodoncia (voice) | Juan Ortodoncia (voice) |
 Lalo AlcarazAdditional Voices (voice) | Additional Voices (voice) |
| CCarolina ÁngelAdditional Voices (voice) | Additional Voices (voice) |
 Memo AponteAdditional Voices (voice) | Additional Voices (voice) |
| MMarcela Davison AvilesAdditional Voices (voice) | Additional Voices (voice) |
 Liliana Barba MeineckeAdditional Voices (voice) | Additional Voices (voice) |
| EEmmanuel BernalAdditional Voices (voice) | Additional Voices (voice) |
| DDavid BerónAdditional Voices (voice) | Additional Voices (voice) |
