 Bill HaderFlint Lockwood (voice) | Flint Lockwood (voice) |
 Anna FarisSam Sparks (voice) | Sam Sparks (voice) |
 James CaanTim Lockwood (voice) | Tim Lockwood (voice) |
 Will ForteChester V (voice) | Chester V (voice) |
 Andy SambergBrent McHale (voice) | Brent McHale (voice) |
 Benjamin BrattManny (voice) | Manny (voice) |
 Neil Patrick HarrisSteve (voice) | Steve (voice) |
 Terry CrewsEarl Devereaux (voice) | Earl Devereaux (voice) |
 Kristen SchaalBarb (voice) | Barb (voice) |
 Cody CameronBarry / Dill Pickle (voice) | Barry / Dill Pickle (voice) |
 Melissa SturmSentinel Louise / Live Corp Scientist (voice) | Sentinel Louise / Live Corp Scientist (voice) |
 Kris PearnSentinel Peter / Labcoat Jenny (voice) | Sentinel Peter / Labcoat Jenny (voice) |
 Craig KellmanFintly McCallahan / Idea Pants Guy (voice) | Fintly McCallahan / Idea Pants Guy (voice) |
 Khamani GriffinCal Devereaux (voice) | Cal Devereaux (voice) |
 Bridget HoffmanYoung Flint (voice) | Young Flint (voice) |
 Al RokerPatrick Patrickson (voice) | Patrick Patrickson (voice) |
 Steve AltermanAdditional Voices (voice) | Additional Voices (voice) |
 June ChristopherAdditional Voices (voice) | Additional Voices (voice) |
 David CowgillAdditional Voices (voice) | Additional Voices (voice) |
| EEddie FriersonAdditional Voices (voice) | Additional Voices (voice) |
 Elisa GabrielliAdditional Voices (voice) | Additional Voices (voice) |
 Jackie GonneauAdditional Voices (voice) | Additional Voices (voice) |
 Tania GunadiAdditional Voices (voice) | Additional Voices (voice) |
 Wendy HoffmannAdditional Voices (voice) | Additional Voices (voice) |
 Walter JonesAdditional Voices (voice) | Additional Voices (voice) |
 Ashley LambertAdditional Voices (voice) | Additional Voices (voice) |
 Scott MenvilleAdditional Voices (voice) | Additional Voices (voice) |
 David SheinkopfAdditional Voices (voice) | Additional Voices (voice) |
 Peter SiragusaAdditional Voices (voice) | Additional Voices (voice) |
 Marina SquerciatiAdditional Voices (voice) | Additional Voices (voice) |
