Veteran western performers Harry Carey and Marguerite Clayton appeared in three films together from 1923-1924: Desert Driven, Tiger Thompson and, perhaps their best, Canyon of the Fools.
| Actor | Role |
|---|---|
 Harry CareyBob | Bob |
 Marguerite ClaytonMay | May |
| FFred R. StantonJim Harper / Polhill (as Fred Stanton) | Jim Harper / Polhill (as Fred Stanton) |
| JJoe HarrisTerazaz (as Joseph Harris) | Terazaz (as Joseph Harris) |
 Jack CurtisMaricopia | Maricopia |
| CCarmen ArselleIncarnación | Incarnación |
 Charles Le MoyneSwasey (as Charles J. Le Moyne) | Swasey (as Charles J. Le Moyne) |
| VVester PeggKnute | Knute |
 Murdock MacQuarrieSproul | Sproul |
| MMignonne GoldenAurelia | Aurelia |