 John TravoltaBolt (voice) | Bolt (voice) |
 Miley CyrusPenny (voice) | Penny (voice) |
 Susie EssmanMittens (voice) | Mittens (voice) |
 Mark WaltonRhino (voice) | Rhino (voice) |
 Malcolm McDowellDr. Calico (voice) | Dr. Calico (voice) |
 James LiptonThe Director (voice) | The Director (voice) |
 Greg GermannThe Agent (voice) | The Agent (voice) |
 Diedrich BaderVeteran Cat (voice) | Veteran Cat (voice) |
 Nick SwardsonBlake (voice) | Blake (voice) |
 J.P. ManouxTom (voice) | Tom (voice) |
 Dan FogelmanBilly (voice) | Billy (voice) |
 Kari WahlgrenMindy Parker (voice) | Mindy Parker (voice) |
 Chloë Grace MoretzYoung Penny (voice) | Young Penny (voice) |
 Randy PoffoThug (voice) | Thug (voice) |
 Ronn MossDr. Forrester (voice) | Dr. Forrester (voice) |
 Grey DeLislePenny's Mom (voice) | Penny's Mom (voice) |
 Sean DonnellanPenny's TV Dad (voice) | Penny's TV Dad (voice) |
 Lino DiSalvoVinnie (voice) | Vinnie (voice) |
| TTodd CummingsJoey (voice) | Joey (voice) |
 Tim MertensBobby (voice) | Bobby (voice) |
 Kelly HooverEster (voice) | Ester (voice) |
 Brian StepanekMartin (voice) | Martin (voice) |
 Jeff BennettLloyd (voice) | Lloyd (voice) |
 Daran NorrisLouie (voice) | Louie (voice) |
 John DiMaggioSaul (voice) | Saul (voice) |
 Jenny LewisAssistant Director (voice) | Assistant Director (voice) |
 Anne LockhartAdditional Voices (voice) | Additional Voices (voice) |
 Phil LaMarrAdditional Voices (voice) | Additional Voices (voice) |
 June ChristopherAdditional Voices (voice) | Additional Voices (voice) |
| CChristin Ciaccio BriggsAdditional Voices (voice) | Additional Voices (voice) |
