Two hundred years after Lt. Ripley died, a group of scientists clone her, hoping to breed the ultimate weapon. But the new Ripley is full of surprises … as are the new aliens. Ripley must team with a band of smugglers to keep the creatures from reaching Earth.
| Actor | Role |
|---|---|
 Sigourney WeaverRipley | Ripley |
 Winona RyderCall | Call |
 Dominique PinonVriess | Vriess |
 Ron PerlmanJohner | Johner |
 Gary DourdanChristie | Christie |
 Michael WincottElgyn | Elgyn |
 Kim FlowersHillard | Hillard |
 Dan HedayaGeneral Perez | General Perez |
 J.E. FreemanDr. Wren | Dr. Wren |
 Brad DourifGediman | Gediman |
 Raymond CruzDistephano | Distephano |
 Leland OrserPurvis | Purvis |
 Carolyn CampbellAnesthesiologist | Anesthesiologist |
| MMarlene BushScientist | Scientist |
 David St. JamesSurgeon | Surgeon |
| RRodney MitchellSoldier with Glove | Soldier with Glove |
| RRobert FaltiscoSoldier Shot Through Helmet | Soldier Shot Through Helmet |
 David RoweFrozen Soldier | Frozen Soldier |
| GGarrett HouseSoldier | Soldier |
 Rod DamerSoldier | Soldier |
| MMark MansfieldSoldier | Soldier |
 Daniel RaymontSoldier | Soldier |
 Cris D'AnnunzioSoldier | Soldier |
| SSteven GilbornFather (voice) | Father (voice) |
 Robert BastensSleeper | Sleeper |
 Rico BuenoSleeper | Sleeper |
 Alex LorreSleeper | Sleeper |
| RRonald RamessarSleeper | Sleeper |
| NNicole FellowsYoung Ripley | Young Ripley |
 Tom Woodruff Jr.Lead Alien | Lead Alien |