 Tom WaitsThe Narrator (voice) | The Narrator (voice) |
 Jimmi SimpsonDetective David Mills (voice) | Detective David Mills (voice) |
 Da'Vine Joy RandolphDetective Gail Johnson (voice) | Detective Gail Johnson (voice) |
 John C. ReillyDonovan Smith (voice) | Donovan Smith (voice) |
 Bebe NeuwirthLady Andrea The Giant (voice) | Lady Andrea The Giant (voice) |
 Jason MantzoukasTim Snodgrass (voice) | Tim Snodgrass (voice) |
 Damon HerrimanStreet Hustler Boy (voice) | Street Hustler Boy (voice) |
 Melissa VillaseñorSister Mary Margaret (voice) | Sister Mary Margaret (voice) |
 Kurtwood SmithCarpenter K. Smith (voice) | Carpenter K. Smith (voice) |
 Tim HeideckerMayor Kevin De Maximum (voice) | Mayor Kevin De Maximum (voice) |
 Chris ConradDetective Nico Onasis (voice) | Detective Nico Onasis (voice) |
 Hana Mae LeeChristina Smalls (voice) | Christina Smalls (voice) |
 Alia ShawkatLittle Grace (voice) | Little Grace (voice) |
 Julian BarrattThe Most Dangerous Man in the World (voice) | The Most Dangerous Man in the World (voice) |
 Kristen BellDonella Pecker (voice) | Donella Pecker (voice) |
 Luis GuzmánRodrigo Smalls (voice) | Rodrigo Smalls (voice) |
 Sunita ManiDetective Jaya Mukherjee (voice) | Detective Jaya Mukherjee (voice) |
 Caleb McLaughlinTrevor Johnson (voice) | Trevor Johnson (voice) |
 Tim MeadowsJeff Thumb (voice) | Jeff Thumb (voice) |
 Terry O'QuinnCaptain Krieger (voice) | Captain Krieger (voice) |
 Dax ShepardChris Pecker (voice) | Chris Pecker (voice) |
 Debra WingerTrish McSapphire (voice) | Trish McSapphire (voice) |
