A preacher sets out on a mission to make the almighty himself confess his sin of abandoning the world. With his best friend Cassidy, an alcoholic Irish vampire, his love Tulip, a red blooded gun towing Texan, and the power of genesis, an unholy child born from an angel and a devil, Jesse gives up everything to set the world straight with its creator.
| Actor | Role |
|---|---|
 Dominic CooperJesse Custer | Jesse Custer |
 Ruth NeggaTulip O'Hare | Tulip O'Hare |
 Joseph GilgunCassidy | Cassidy |
 Ian CollettiEugene 'Arseface' Root | Eugene 'Arseface' Root |
 Graham McTavishSaint of Killers | Saint of Killers |
 Pip TorrensHerr Starr | Herr Starr |
 Tyson RitterHumperdoo / Jesus Christ | Humperdoo / Jesus Christ |
 Noah TaylorHitler | Hitler |
 Julie Ann EmeryLara Featherstone | Lara Featherstone |
 Mark HarelikGod | God |