Set in the future, Major Lazer is a Jamaican superhero who fights against the dystopian forces that have ruined society that are led by President Whitehall and General Rubbish. Major Lazer is assisted in his fight by President Whitehall's daughter Penny and hacker Blkmrkt.
| Actor | Role |
|---|---|
 Adewale Akinnuoye-AgbajeMajor Lazer (voice) | Major Lazer (voice) |
 James AdomianGeneral Rubbish (voice) | General Rubbish (voice) |
 John BoyegaBlkmrkt (voice) | Blkmrkt (voice) |
| AAshante 'Taranchyla' ReidOld Rasta / PG Tipps / Weed Man (voice) | Old Rasta / PG Tipps / Weed Man (voice) |
 J.K. SimmonsPresident Whitewall (voice) | President Whitewall (voice) |
 Angela TrimburPenny Whitewall (voice) | Penny Whitewall (voice) |