The events of Police District unfold in the rooms of the 10th Tuscolano, a police station on the outskirts of Rome where current events intertwine with the private lives of the inspectors, officers and commissioners who, over the course of 11 intense seasons, have created one of the greatest successes on Italian TV.
| Actor | Role |
|---|---|
 Simone CorrenteLuca Benvenuto | Luca Benvenuto |
 Marco MarzoccaUgo Lombardi | Ugo Lombardi |
 Lucilla AgostiBarbara Rostagno | Barbara Rostagno |
 Dino AbbresciaPietro Esposito | Pietro Esposito |
 Gianluca BazzoliGiovanni Brenta | Giovanni Brenta |
 Andrea RenziLeonardo Brandi | Leonardo Brandi |
 Paolo CalabresiOtello Gagliardi | Otello Gagliardi |
 Maria Amelia MontiAnita Cherubini | Anita Cherubini |
| SStefano VialiAldo Boni | Aldo Boni |
 Antonino BruschettaMarco Gallo | Marco Gallo |
 Tommaso RagnoAntonio Corallo | Antonio Corallo |
 Miriam LeoneMara Fermi | Mara Fermi |
 Massimo BonettiRocco Liverani | Rocco Liverani |
 Patrizio PelizziFlavio De Mola | Flavio De Mola |