High school mathlete Lindsay Weir rebels and begins hanging out with a crowd of burnouts (the "freaks"), while her brother Sam Weir navigates a different part of the social universe with his nerdy friends (the "geeks").
| Actor | Role |
|---|---|
 John Francis DaleySam Weir | Sam Weir |
 Linda CardelliniLindsay Weir | Lindsay Weir |
 James FrancoDaniel Desario | Daniel Desario |
 Samm LevineNeal Schweiber | Neal Schweiber |
 Martin StarrBill Haverchuck | Bill Haverchuck |
 Jason SegelNick Andopolis | Nick Andopolis |
 Seth RogenKen Miller | Ken Miller |
 Joe FlahertyHarold Weir | Harold Weir |
 Becky Ann BakerJean Weir | Jean Weir |