Every day is a matter of life and death in a hectic New York City hospital, but for Nurse Jackie that's the easiest part. Between chronic back pain that won't quit, and a personal life on the constant edge of collapse, it's going to take a white lie here, a bent rule there, and a handful of secret strategies to relieve the pain, and stay one step ahead of total disaster.
| Actor | Role |
|---|---|
 Edie FalcoJackie Peyton | Jackie Peyton |
 Merritt WeverZoey Barkow | Zoey Barkow |
 Paul SchulzeEddie Walzer | Eddie Walzer |
 Dominic FumusaKevin Peyton | Kevin Peyton |
 Anna Deavere SmithGloria Akalitus | Gloria Akalitus |
 Stephen WallemThor Lundgren | Thor Lundgren |
 Betty GilpinDr. Carrie Roman | Dr. Carrie Roman |
 Ruby JerinsGrace Peyton | Grace Peyton |
 Mackenzie AladjemFiona Peyton | Fiona Peyton |