Intergalactic bounty hunters Iria and Bob return to track down an ancient mystical relic. When a second Zeiram unit shows up and goes berserk, it takes all of Iria's resources to survive a deadly game of cat-and-mouse with the fearsome space creature.
| Actor | Role |
|---|---|
 Yûko MoriyamaIria | Iria |
 Kazuhiko InoueBob | Bob |
| MMizuho YoshidaYanuki / Zeiram | Yanuki / Zeiram |
 SABUFujikuro (as Sabu) | Fujikuro (as Sabu) |
 Kunihiko IdaTeppei | Teppei |
 Yukijiro HotaruKamiya | Kamiya |
| MMitsuo AbeHagi | Hagi |
| SShuta HiromotoShaman, Various Bad Guys | Shaman, Various Bad Guys |
| BBin KuriharaKanute | Kanute |
| MMakio HiraiwaElectronics store manager | Electronics store manager |
 Yukitomo TochinoMurata | Murata |
 Tetsu WatanabeTaguchi | Taguchi |
| KKazuhiro YokoyamaKoma Dog | Koma Dog |
| YYoichi KomatsuzawaMan Asking for Directions | Man Asking for Directions |
| KKatsuya TeradaSoba shop clerk | Soba shop clerk |
| RReo KinueWoman in a miniskirt | Woman in a miniskirt |
| YYumiko KishimaWoman in a miniskirt | Woman in a miniskirt |
| AAya KaidaBounty Hunter | Bounty Hunter |
| TTakeshi KonudaBounty Hunter | Bounty Hunter |