 Meg RyanKathleen Kelly | Kathleen Kelly |
 Tom HanksJoe Fox | Joe Fox |
 Greg KinnearFrank Navasky | Frank Navasky |
 Parker PoseyPatricia Eden | Patricia Eden |
 Heather BurnsChristina Plutzker | Christina Plutzker |
 Dave ChappelleKevin Jackson | Kevin Jackson |
 Jean StapletonBirdie Conrad | Birdie Conrad |
 Steve ZahnGeorge Pappas | George Pappas |
 Dabney ColemanNelson Fox | Nelson Fox |
 John RandolphSchulyer Fox | Schulyer Fox |
 Hallee HirshAnnabelle Fox | Annabelle Fox |
 Jeffrey ScaperrottaMatt Fox | Matt Fox |
 Cara SeymourGillian Quinn | Gillian Quinn |
 Katie FinneranMaureen, the Nanny | Maureen, the Nanny |
 Michael BadaluccoCharlie | Charlie |
 Deborah RushVeronica Cash | Veronica Cash |
 Veanne CoxMiranda Margulies | Miranda Margulies |
 Bruce Jay FriedmanVince Mancini | Vince Mancini |
 Sara RamirezRose, Zabars Cashier | Rose, Zabars Cashier |
| HHoward SpiegelHenry, Zabars Shopper | Henry, Zabars Shopper |
 Diane SokolowZabars Shopper | Zabars Shopper |
| JJulie KassZabars Shopper | Zabars Shopper |
 Reiko AylesworthThanksgiving Guest | Thanksgiving Guest |
 Katie SagonaYoung Kathleen Kelly | Young Kathleen Kelly |
 Kathryn MeisleCecilia Kelly | Cecilia Kelly |
| NNina Zoie LamT.V. Reporter | T.V. Reporter |
| MMaggie MurphyTheater Patron | Theater Patron |
| MMichelle BlakelyShopper | Shopper |
| MMeredith WhiteShopper | Shopper |
| DDianne DreyerShopper | Shopper |
