 Nicholas RoweSherlock Holmes | Sherlock Holmes |
| AAlan CoxJohn Watson | John Watson |
 Sophie WardElizabeth Hardy | Elizabeth Hardy |
 Anthony HigginsProfessor Rathe | Professor Rathe |
 Susan FleetwoodMrs. Dribb | Mrs. Dribb |
 Roger Ashton-GriffithsDet. Sgt. Lestrade | Det. Sgt. Lestrade |
| MMatthew RyanDudley's Friend | Dudley's Friend |
| EEarl RhodesDudley | Dudley |
 Freddie JonesChester Cragwitch | Chester Cragwitch |
 Patrick NewellBentley Booster | Bentley Booster |
 Nadim SawalhaKhasek - Lower Nile Tavern Owner | Khasek - Lower Nile Tavern Owner |
 Nigel StockRupert T. Waxflatter | Rupert T. Waxflatter |
 Brian OultonMaster Snelgrove | Master Snelgrove |
| DDonald EcclesThe Reverend Duncan Nesbitt | The Reverend Duncan Nesbitt |
| MMatthew BlakstadDudley's Friend | Dudley's Friend |
| JJonathan LaceyDudley's Friend | Dudley's Friend |
 Walter SparrowEthan Engel | Ethan Engel |
 Roger BrierleyMr. Holmes | Mr. Holmes |
 Vivienne ChandlerMrs. Holmes | Mrs. Holmes |
 Lockwood WestCurio Shop Owner | Curio Shop Owner |
| JJohn Scott MartinCemetery Caretaker | Cemetery Caretaker |
 George MalpasSchool Porter | School Porter |
 Willoughby GoddardSchool Reverend | School Reverend |
 Michael CulePoliceman with Lestrade | Policeman with Lestrade |
 Ralph TabakinPoliceman in Shop Window | Policeman in Shop Window |
 Nancy NevinsonHotel Receptionist | Hotel Receptionist |
 Michael HordernOlder Watson (voice) | Older Watson (voice) |
| GGrant BurnsSchoolboy (uncredited) | Schoolboy (uncredited) |
| GGeorge Lane CooperAcolyte (uncredited) | Acolyte (uncredited) |
 Salo GardnerChestnut Seller (uncredited) | Chestnut Seller (uncredited) |
