In the early 16th century Italy is ruled by the powerful Borgia family, led by Cesare Borgia and his sister Lucrezia. In a ruthless power play, Cesare plots to have his sister’s husband murdered.
| Actor | Role |
|---|---|
 Simonetta StefanelliLucrezia Borgia | Lucrezia Borgia |
 Massimo FoschiCesare Borgia | Cesare Borgia |
 Ettore ManniRodrigo Borgia - Papa Alessandro VI | Rodrigo Borgia - Papa Alessandro VI |
 Anna OrsoGiovanna Cattanei | Giovanna Cattanei |
 Paolo MalcoJuan de Candia Borgia | Juan de Candia Borgia |
 Elizabeth TurnerGiulia | Giulia |
 Fred RobsahmAlfonso d'Aragona | Alfonso d'Aragona |
 Aldo ReggianiGiovanni Sforza | Giovanni Sforza |
| RRaffaele CuriPerotto | Perotto |
 Piero LulliLudovico Maria Sforza 'il Moro' | Ludovico Maria Sforza 'il Moro' |
 Teodoro CorràCardinale Sisto Borgia | Cardinale Sisto Borgia |
| EEdoardo FlorioThe Pope's Private Secretary | The Pope's Private Secretary |
 Annamaria TornelloNot listed | Not listed |
 Margaret Rose KeilNot listed | Not listed |