New York City, 1897. A little girl named Virginia O'Hanlon loves Christmas more than anything else in the world. When a schoolyard bully challenges her belief in Santa Claus, Virginia embarks on a quest across the city to prove he is real. Based on the true story of the most famous newspaper editorial of all time.
| Actor | Role |
|---|---|
 Neil Patrick HarrisDr. Philip O'Hanlon (voice) | Dr. Philip O'Hanlon (voice) |
 Bea MillerVirginia O'Hanlon (voice) | Virginia O'Hanlon (voice) |
 Jennifer Love HewittMrs. Laura O'Hanlon (voice) | Mrs. Laura O'Hanlon (voice) |
 Alfred MolinaFrancis Church (voice) | Francis Church (voice) |
| RRobb PruittSanta (voice) | Santa (voice) |
 Andrew CherryGeorge (voice) | George (voice) |
| TTaylor HayTaylor (voice) | Taylor (voice) |
 Michael BuscemiScraggly Santa (voice) | Scraggly Santa (voice) |