A secretary's life changes in unexpected ways after her dog dies.
| Actor | Role |
|---|---|
 Molly ShannonPeggy | Peggy |
 Laura DernBret | Bret |
 Regina KingLayla | Layla |
 Tom McCarthyPier | Pier |
 Josh PaisRobin | Robin |
 John C. ReillyAl | Al |
 Peter SarsgaardNewt | Newt |
 Dale GodboldoDon | Don |
 Liza WeilTrishelle | Trishelle |
 Amy SchlagelLissie | Lissie |
| ZZoe SchlagelLissie | Lissie |
| UUrsula BraunerDog Owner | Dog Owner |
| SSusan MackinSusan | Susan |
| IInara GeorgeHolly | Holly |
| CChristy MooreAl's Girlfriend | Al's Girlfriend |
 Audrey WasilewskiAudrey | Audrey |
 Brenda CanelaBrenda | Brenda |
 Sonya EddyNurse | Nurse |
| JJon SherePound Employee | Pound Employee |
 Steve BergSteve | Steve |