 Jessica ChastainCatherine Weldon | Catherine Weldon |
 Michael GreyeyesSitting Bull | Sitting Bull |
 Sam RockwellSilas Groves | Silas Groves |
 Ciarán HindsJames McLaughlin | James McLaughlin |
 Chaske SpencerChaska | Chaska |
 Bill CampGeneral Crook | General Crook |
| WWilly RunsAboveChief Black Bear | Chief Black Bear |
 Louisa KrauseLoretta | Loretta |
 Robert MirabalOnly Man | Only Man |
| MMonika CrowfootSeen By The Nation | Seen By The Nation |
 David MidthunderShell King | Shell King |
| RRulan TangenSusan McLaughlin | Susan McLaughlin |
| RRobert Moreno Sr.Thunder | Thunder |
| BBen ZieglerAttacker in Cannonball | Attacker in Cannonball |
 Boots SoutherlandCab Driver NY | Cab Driver NY |
| BBen Black BearChief | Chief |
 Rachel SingerDry Goods Assistant | Dry Goods Assistant |
 Andersen KeeIndian Policeman | Indian Policeman |
| CCosme DuarteIndian Policeman | Indian Policeman |
| RRod RondeauxIndian Robber | Indian Robber |
 Luce RainsOld Man at Train Station | Old Man at Train Station |
| DDebbie Black LanceOld Sioux Woman | Old Sioux Woman |
| MMakayah Starley CrowfootSioux Child | Sioux Child |
 DezBaa'Sioux Woman at Ration Day | Sioux Woman at Ration Day |
| LLyle SandovalTracker | Tracker |
 Jacob BrowneWaiter in Dining Car | Waiter in Dining Car |
| KKindall ChartersWaiter in Sleeping Car | Waiter in Sleeping Car |
| SSusan ConklinWoman in Cannonball | Woman in Cannonball |
 Brenda WehleAnna Maria Valentine (uncredited) | Anna Maria Valentine (uncredited) |
| DDavid HightCavalry Lt. (uncredited) | Cavalry Lt. (uncredited) |
