 Spencer TracySam Craig | Sam Craig |
 Katharine HepburnTess Harding | Tess Harding |
 Fay BainterEllen Whitcomb | Ellen Whitcomb |
 Reginald OwenClayton | Clayton |
 Minor WatsonWilliam J. Harding | William J. Harding |
 William BendixPinkie Peters | Pinkie Peters |
 Gladys BlakeFlo Peters | Flo Peters |
 Dan TobinGerald Howe | Gerald Howe |
 Roscoe KarnsPhil Whittaker | Phil Whittaker |
 William TannenEllis | Ellis |
 Ludwig StösselDr. Lubbeck | Dr. Lubbeck |
 Sara HadenMatron | Matron |
 Edith EvansonAlma | Alma |
| GGeorge KezasChris | Chris |
| JJimmy AmesCab Driver (uncredited) | Cab Driver (uncredited) |
| HHerbert AshleyStage Doorman (uncredited) | Stage Doorman (uncredited) |
| DDorothy AtesPhone Girl (uncredited) | Phone Girl (uncredited) |
 William BaileyBaseball Fan (uncredited) | Baseball Fan (uncredited) |
 Brooks BenedictClayton's Secretary (uncredited) | Clayton's Secretary (uncredited) |
 John BerkesPal (uncredited) | Pal (uncredited) |
 Symona BonifaceTess' Party Guest (uncredited) | Tess' Party Guest (uncredited) |
| EElfriede BorodinLeni (uncredited) | Leni (uncredited) |
| JJack CarrBaseball Spectator Behind Tess (uncredited) | Baseball Spectator Behind Tess (uncredited) |
 Ruth CherringtonForeigner (uncredited) | Foreigner (uncredited) |
 Ann CodeeMadame Sylvia (uncredited) | Madame Sylvia (uncredited) |
 Jimmy ConlinReporter at Bar (uncredited) | Reporter at Bar (uncredited) |
 Jules CowlesJoe (uncredited) | Joe (uncredited) |
| FFloyd CriswellPoliceman (uncredited) | Policeman (uncredited) |
 Fern EmmettMrs. Calverton (uncredited) | Mrs. Calverton (uncredited) |
| CCurt FurburgForeigner (uncredited) | Foreigner (uncredited) |
