Williamsburg: the Story of a Patriot tells the story of Virginia's role in American Independence (up to the point of voting to propose independence at the Second Continental Congress), from the point of view of John Fry (played by a young Jack Lord), a fictional Virginia planter elected to the House of Burgesses.
| Actor | Role |
|---|---|
 Jack LordJohn Fry | John Fry |
 Leora DanaAnne Fry | Anne Fry |
| MMargery MaudeMadam Fry | Madam Fry |
| RRichard StrikerRobert Fry | Robert Fry |
| KKarin WolfeCaroline Fry | Caroline Fry |
| RRobert CarrollPatrick Henry | Patrick Henry |
 Charles G. MartinGeorge Washington | George Washington |
| FFrederic WarrinerThomas Jefferson | Thomas Jefferson |
 Francis ComptonGeorge Wythe | George Wythe |
| MMichael LaurenceJohn Randolph | John Randolph |
| RRalph SumpterPeyton Randolph | Peyton Randolph |
 House JamesonWilliam Byrd III | William Byrd III |
| CClarence DerwentLord Botetourt | Lord Botetourt |
| JJohn GoodbodyThe Reverend Mr. Price | The Reverend Mr. Price |
| OOrin M. Bullock Jr.Richard Henry Lee | Richard Henry Lee |