 Will SmithCapt. James West | Capt. James West |
 Kevin KlineU.S. Marshal Artemus Gordon / President Grant | U.S. Marshal Artemus Gordon / President Grant |
 Kenneth BranaghDr. Arliss Loveless | Dr. Arliss Loveless |
 Salma Hayek PinaultRita Escobar | Rita Escobar |
 M. Emmet WalshColeman | Coleman |
 Ted LevineGeneral 'Bloodbath' McGrath | General 'Bloodbath' McGrath |
 Frederique van der WalAmazonia | Amazonia |
 Musetta VanderMunitia | Munitia |
 Sofia EngMiss Lippenrieder | Miss Lippenrieder |
 Bai LingMiss Mae Lee East | Miss Mae Lee East |
 Garcelle BeauvaisBelle (Girl in Water Tower) | Belle (Girl in Water Tower) |
| MMike H. McGaughyBig reb | Big reb |
 Jerry WillsOther Reb | Other Reb |
 Rodney A. GrantHudson | Hudson |
 Buck TaylorCross-Eyed Reb | Cross-Eyed Reb |
 E.J. CallahanMr. Pinkerton | Mr. Pinkerton |
 Debra ChristoffersonDora Look-Alike | Dora Look-Alike |
 James LashlyReb #1 | Reb #1 |
 Dean Rader DuvalReb #2 | Reb #2 |
| CChristian AubertFrench Dignitary | French Dignitary |
 Orestes MatacenaSpanish Dignitary | Spanish Dignitary |
 Ian AbercrombieBritish Dignitary | British Dignitary |
 Ismael 'East' CarloMexican Dignitary | Mexican Dignitary |
 Bob RumnockWhite House Aide | White House Aide |
 Gary Carlos CervantesDr. Guillermo Escobar | Dr. Guillermo Escobar |
 Jerry PotterGeorge Washington | George Washington |
 Mik ScribaGuard | Guard |
| MMichael SimsProf. Thaddeus Morton | Prof. Thaddeus Morton |
 J.J. PerryShovel Guy (uncredited) | Shovel Guy (uncredited) |
 Dennis KeifferWrench Guy (uncredited) | Wrench Guy (uncredited) |
