A dachshund passes from oddball owner to oddball owner, whose radically dysfunctional lives are all impacted by the pooch.
| Actor | Role |
|---|---|
 Ellen BurstynNana | Nana |
 Kieran CulkinBrandon McCarthy | Brandon McCarthy |
 Julie DelpyDina | Dina |
 Danny DeVitoDave Schmerz | Dave Schmerz |
 Greta GerwigDawn Wiener | Dawn Wiener |
 Tracy LettsDanny | Danny |
 Zosia MametZoe | Zoe |
 Keaton Nigel CookeRemi | Remi |
| HHaraldo AlvarezLuis | Luis |
| RRigoberto GarciaJose | Jose |
| DDain VictorianioJose Luis | Jose Luis |
| CConnor LongTommy | Tommy |
| BBridget BrownApril | April |
 Sharon WashingtonPhillips | Phillips |
 Devin DruidDwight | Dwight |
| TTrey SilverPeter Jacobson | Peter Jacobson |
 Ari GraynorCarol Steinhart | Carol Steinhart |
 Birkett TurtonDirector | Director |
 Samrat ChakrabartiDr. Farhard Rahman | Dr. Farhard Rahman |
 Trey GerraldZeno | Zeno |
| CClara MametLina | Lina |
 Katherine ReisRafa | Rafa |
 Charlie TahanWarren | Warren |
| MMelo LudwigYoung Nana | Young Nana |
 Michael James ShawFantasy | Fantasy |
 Marcella LoweryYvette | Yvette |
 Jen PontonKristy | Kristy |
 Alexis SuarezPolice Officer | Police Officer |
 Andrew PangWong | Wong |
| SScott MartinStreet Vendor | Street Vendor |