 John BarrymoreChevalier Fabien des Grieux | Chevalier Fabien des Grieux |
 Dolores CostelloManon Lescaut | Manon Lescaut |
 Warner OlandAndré Lescaut | André Lescaut |
 Sam De GrasseComte Guillot de Morfontaine | Comte Guillot de Morfontaine |
 Holmes HerbertJean Tiberge | Jean Tiberge |
 Stuart HolmesLouis XV - King of France | Louis XV - King of France |
 Bertram GrassbyLe Duc de Richelieu | Le Duc de Richelieu |
 Tom SantschiCaptain of Convict Boat | Captain of Convict Boat |
 Alice BelcherMinor Role (uncredited) | Minor Role (uncredited) |
 Eugenie BessererThe Landlady (uncredited) | The Landlady (uncredited) |
 Charles ClaryA Lay Brother (uncredited) | A Lay Brother (uncredited) |
 Marcelle CordayMarie (uncredited) | Marie (uncredited) |
 Rose DioneNana (uncredited) | Nana (uncredited) |
 Louise EmmonsSmiling Hag (uncredited) | Smiling Hag (uncredited) |
| HHerman HellerHimself - Orchestra Conductor (End Credit) (uncredited) | Himself - Orchestra Conductor (End Credit) (uncredited) |
 Noble JohnsonAggresive Apache (uncredited) | Aggresive Apache (uncredited) |
 Jack KennyMinor Role (uncredited) | Minor Role (uncredited) |
| GGeorge KotsonarosConvict Prisoner (uncredited) | Convict Prisoner (uncredited) |
 Myrna LoyConvict Behind Manon (uncredited) | Convict Behind Manon (uncredited) |
| AAndy MacLennanMan Trying to Trick Manon into His House (uncredited) | Man Trying to Trick Manon into His House (uncredited) |
 Ida MayMinor Role (uncredited) | Minor Role (uncredited) |
 Kalla PashaOfficer on Prisoner Ship (uncredited) | Officer on Prisoner Ship (uncredited) |
 Russ PowellInnkeeper (uncredited) | Innkeeper (uncredited) |
 Templar SaxeBaron Chevral (uncredited) | Baron Chevral (uncredited) |
 Scott SeatonBishop (uncredited) | Bishop (uncredited) |
 Dick SutherlandTavern Waiter (uncredited) | Tavern Waiter (uncredited) |
 Tom WilsonA Convict Aboard the Boat (uncredited) | A Convict Aboard the Boat (uncredited) |
