Sylvester Cat is a guard at a Mexican experimental laboratory where mice are confined for research. The families of the captured mice place a call to Speedy Gonzales, the fastest mouse in Mexico, to help them rescue their compadres. Speedy comes and engages in the usual battle of wits and feet with Sylvester.
| Actor | Role |
|---|---|
 Mel BlancSpeedy Gonzales / Sylvester / Mice (voice) | Speedy Gonzales / Sylvester / Mice (voice) |
| TTom HollandMice (voice) (uncredited) | Mice (voice) (uncredited) |